Talk to Endocrinologist on CAH

Prof. Dr. Jaida Manzoor - Pediatric Endocrinologist

MBBS, FCPS | Lahore

469 Positive Reviews

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Get your appointment : Dr. Jaida Manzoor Pediatric Endocrinologist
Hammed Latif Hospital Lahore
Friday Saturday 4-5pm

Dr. Zulfiqar Ahmed - Endocrinologist

MBBS, MRCP (UK) | Abbottabad

84 Positive Reviews

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Hi. Good day. Congenital adrenal hyperplasia is a metabolic disorder related to enzymatic defects in the production of steroids. Typically the defects are inherited in an autosomal recessive manner, and within a particular family all inherit the same enzyme deficiency.Two principal effects result from the enzyme deficiency:
deficient cortisol and/or aldosterone production
excess precursor steroids
In response, there is increased ACTH secretion from the anterior pituitary producing adrenocortical hyperplasia.
At least eight distinctive clinical syndromes are recognised but the majority of cases are attributed to:
21-hydroxylase deficiency (approximately 95%)
11-beta-hydroxylase deficiency (approximately 5%)
The deficiency forms of CAH which are associated:
with male pseudohermaphrodite include 21alpha-hydroxylase and to a lesser extent 11-beta-hydroxylase
with female pseudohermaphrodite include 17alpha-hydroxylase, 17,20 lyase, 3beta-hydroxysteroid dehydrogenase, and cholesterol 20,22 desmolase;
while CAH forms which are associated with hypertension include 17alpha-hydroxylase and 11beta-hydroxylase deficiency. Are u already diagnosed with CAH ?Please make online appointment Thanks