Talk to General Physician on Diabetic, Hypertension

My mother is diabetic patient since 14 years also suffering from hypertension, she is taking mixtard-30 insulin from also she is obessive overweight. from last one month she is taking concor , rusovastatin, ascard and losartan k with this medicine she feels belly pain and loose motion also now she suffer from pain with urine and urine not comes easily the urine problem is not for the first time it comes in 3or 4months and some time control with cifroflaxacin and some time abtibiotic injection like 2 sum. every month i do her ultrasound urea and creatine test. her creatinine is 0.9 in the range of 0.6-1.2 and blood urea is 40 . plz suggest me to prevent her from kidney disease and control her creatune blood urea level and every thing bcz i love my mother .