Entamizole tablet is a combination medication that contains Diloxanide and Metronidazole, which work together to treat certain bacterial and protozoal infections. It is primarily used to treat amoebiasis and other parasitic infections.
Manufactured by: Abbott Pharmacy
Generic: Diloxanide Furoate and Metronidazole Benzoate
Drug class: Antibiotics
Product form: Tablet
Mechanism of Action
The mechanism of action of Entamizole involves the inhibition of DNA synthesis in the targeted parasites, leading to their death. This is achieved through the actions of its active ingredients, Diloxanide and Metronidazole.
Available Strengths
This tablet contains the following two combinations;
- Entamizole – Diloxanide furoate 250mg/ Metronidazole 200mg
- Entamizole DS – Diloxanide furoate 400mg/ Metronidazole 500mg
What is Entamizole tablet Price in Pakistan?
Entamizole 500/400 mg tablet price in Pakistan ranges between 7-10 PKR per tablet. The tablet price varies depending on the strength and manufacturer.
What is the Entamizole tablet used for?
The Entamizole tablet uses include;
- Amoebiasis: Entamizole is an effective treatment for amoebiasis, an infection caused by amoebae that can lead to symptoms such as diarrhea, abdominal pain, and fever.
- Giardiasis: This tablet may treat giardiasis, a parasitic infection that can cause diarrhea, abdominal cramps, and bloating.
- Bacterial vaginosis: This medication can also be prescribed to treat bacterial vaginosis, a condition caused by an overgrowth of bacteria in the vagina that can lead to vaginal discharge and odour.
- Trichomoniasis: It is sometimes used to treat trichomoniasis, a sexually transmitted infection (STI) caused by a parasite that can cause vaginal discharge, itching, and pain during urination.
It is important to note that Entamizole should only be used as prescribed by a doctor and not to treat infections for which it has not been specifically prescribed.
How to take the Entamizole tablet?
Follow these general instructions for taking an Entamizole tablet;
- Entamizole tablets are typically taken orally, with or without food, as directed by a doctor.
- The tablets should be swallowed whole and not crushed or chewed.
- The dosage and duration of treatment will depend on the individual’s medical condition and should be determined by the doctor.
- It is important to complete the full course of treatment, even if symptoms improve before the prescribed dose ends.
What is Entamizole dosage?
The recommended dosage of Entamizole may vary depending on the individual’s medical condition. Here are some general guidelines on the dosages of Entamizole:
- For amoebiasis: 1-2 tablets (400 mg of Diloxanide and 500 mg of Metronidazole) taken orally 3 times a day for 5-10 days.
- For bacterial vaginosis: 1 tablet (400 mg of Diloxanide and 500 mg of Metronidazole) taken orally twice a day for 5-7 days.
- For giardiasis and trichomoniasis: 2 tablets (400 mg of Diloxanide and 500 mg of Metronidazole) taken orally twice a day for 5-7 days.
The dosage and duration of treatment may need to be adjusted based on the individual’s response to the medication and any side effects experienced.
It is important to consult a doctor to get an appropriate dosage for the tablet.
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What are Entamizole tablet side effects?
Entamizole tablets can cause side effects, although not everyone who takes them will experience them. Some possible side effects of Entamizole tablet include:
- Loss of appetite
- Blurred or double vision
- Metallic taste in the mouth
- Dark urine or pale stools
- Brain disease
- Anemia due to hemolysis
In rare cases, Entamizole tablets may cause more serious side effects, such as seizures, severe allergic reactions, or blood disorders. If you experience any more serious side effects, seek medical attention immediately.
What are the warnings associated with the Entamizole tablet?
The precautions and warnings associated with Entamizole use include;
- Entamizole should be used with caution in patients with liver or kidney disease, as it can affect the function of these organs.
- Patients with a history of blood disorders or seizures should use Entamizole cautiously, as it may worsen these conditions.
- It should not be taken by patients who are allergic to any ingredients in the medication.
- This medicine may interact with certain medications, including blood thinners and disulfiram, so patients should inform their healthcare provider of all their medications.
- This tablet may affect a patient’s ability to drive or operate machinery, so patients should exercise caution when performing these activities.
- Patients should complete the full course of treatment with Entamizole, even if symptoms improve, to prevent the development of antibiotic resistance.
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Does an Entamizole tablet react with medicines?
Here are some medications that may interact with Entamizole tablet:
- Warfarin
- Disulfiram
- Lithium
- Phenytoin
- Cimetidine
- Fluorouracil
- Busulfan
Is Entamizole Tablet Safe during Pregnancy?
Entamizole is classified as a pregnancy category C medication, meaning that animal studies have shown some potential for fetal harm. Still, there are no adequate and well-controlled studies in humans.
Therefore, it is recommended that pregnant women consult with a gynecologist before taking Entamizole or any other medication. Alternatively, alternative medications may be recommended to treat bacterial or parasitic infections during pregnancy.
Additionally, women planning to become pregnant should inform their healthcare provider before starting treatment with Entamizole, as the medication may affect fertility.
What are the alternatives to the Entamizole tablet?
Some of the alternative brands for Entamizole tablets are;
It is important to note that the choice of medication will depend on the type and severity of the infection being treated and individual patient factors such as age, medical history, and other medications being taken.
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What happens with an Entamizole tablet Overdose?
Taking an overdose of Entamizole tablets may result in symptoms such as nausea, vomiting, headache, and confusion. In severe cases, it may lead to seizures, coma, or respiratory depression, and immediate medical attention should be sought.
What happens if you miss the Entamizole dose?
If you miss a dose of Entamizole tablet, taking it as soon as possible is recommended. However, if it is close to the time of the next dose, it is advisable to skip the missed dose and resume the regular dosing schedule. Do not take a double dose to make up for the missed one.
How to store Entamizole tablets?
Here are some guidelines for storing Entamizole tablets:
- Store Entamizole tablets at room temperature between 15-30°C (59-86°F).
- Keep the medication out of reach of children and pets.
- Protect the tablets from moisture, light, and heat.
- Do not use the medication after the expiration date.
- If the tablets are discoloured, cracked, or damaged, do not use them.
- Do not dispose of Entamizole tablets in household waste; consult local guidelines for proper disposal.
If you have more questions about taking Entamizole, consult with a doctor for bacterial infections.
FAQs
1. Can you take Entamizole with milk?
It is generally recommended to avoid consuming milk or other dairy products while taking Entamizole tablets, as they may reduce the effectiveness of the medication. Dairy products may also interfere with the absorption of the medication in the body.
2. How do you stop diarrhea fast?
Some sensible options include water, Pedialyte, fruit juices, caffeine-free soda, and salty broths. The experts claim that salt slows fluid loss and that sugar aids in salt absorption.
Disclaimer: The content was published on Marham. pk is for informational or educational purposes only, produced from FDA-approved literature, and does not substitute professional medical advice. Please consult your healthcare provider before using a prescription or over-the-counter drug, or any other treatment option.