Levothyroxine Tablet: Uses, Side Effects, and Price in Pakistan

Levothyroxine is a medication used to treat hypothyroidism, goiter, and certain types of thyroid cancer. It works by supplementing or replacing the thyroid hormone in the body.

Manufactured by: Abbott Ltd
Drug Class: Hormones
Product form: Tablet, Capsule, Solution

Mechanism of Action

Synthetic thyroxine (T4), also known as levothyroxine, is a thyroid hormone that is used to replace or supplement the natural hormone in the body. In order to function, it binds to thyroid hormone receptors in the cell nucleus and activates the production of proteins necessary for healthy metabolism and growth.

Available Strengths

• Levothyroxine tablet 12.5 mcg
• Levothyroxine tablet 25 mcg
• Levothyroxine tablet 50 mcg
• Levothyroxine tablet 75 mcg
• Levothyroxine tablet 100 mcg

What is Levothyroxine tablet Price in Pakistan?

Levothyroxine tablet 50mcg price in Pakistan ranges between 160-180 PKR/ 30 tablets. The tablet price varies depending on the strength and manufacturer.

What is the Levothyroxine tablet used for?

Levothyroxine tablet uses include;

• Treatment of hypothyroidism: Levothyroxine is commonly used to treat hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormone.
• Management of goiter: It can help manage goiter, which is an enlarged thyroid gland that can occur due to various reasons, including iodine deficiency, autoimmune disease, or thyroid nodules.
• Treatment of thyroid cancer: Certain types of thyroid cancer may require treatment with levothyroxine, either alone or in combination with other therapies.
• Management of subclinical hypothyroidism: It can also be used to manage subclinical hypothyroidism, a milder form of hypothyroidism that may not cause noticeable symptoms but can still lead to long-term health problems.
• Support for fertility and pregnancy: In women with hypothyroidism who are trying to conceive or who are pregnant, levothyroxine may be used to support healthy fetal development and reduce the risk of pregnancy complications.

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How to take the Levothyroxine tablet?

Follow these general instructions for taking a Levothyroxine tablet;

• Take the tablet orally, with a full glass of water.
• Ideally, take the tablet at the same time each day, on an empty stomach.
• Do not crush, chew or break the tablet before consumption.
• Follow the dosage instructions provided by your doctor carefully, and do not take more or less than prescribed.
• Inform your doctor of any other medications or supplements you are taking, as they may interact with Levothyroxine.
• Do not stop taking Levothyroxine without consulting your doctor, even if you feel better.

What is Levothyroxine dosage?

Here are some general guidelines for the dosage of Levothyroxine:

• The recommended starting dose for most adults with hypothyroidism is 1.6 mcg per kilogram of body weight per day, taken orally, usually in the morning, at least 30 minutes before eating.
• The dose may be adjusted based on individual response and laboratory test results.
• For elderly patients or patients with underlying cardiac disease, the initial dose should be lower, with gradual titration.
• The dosage of Levothyroxine may need to be adjusted during pregnancy, as thyroid hormone requirements often increase during this time.
• The dosage of Levothyroxine may need to be adjusted if the patient is also taking certain other medications, such as iron supplements or calcium supplements.

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What are Levothyroxine tablet side effects?

Here are the potential side effects of Levothyroxine:

• Hair loss: Levothyroxine can cause hair loss, especially during the initial stages of treatment.
• Weight changes: It can cause weight changes, with some people experiencing weight gain and others experiencing weight loss.
• Sleep disturbances: Some people may experience sleep disturbances, such as insomnia or excessive sleepiness when taking levothyroxine.
• Headaches: Headaches are a common side effect of levothyroxine, especially during the initial stages of treatment.
• Nervousness and irritability: Levothyroxine can cause nervousness, irritability, and anxiety, especially if the dose is too high.
• Palpitations: Some people may experience heart palpitations or a rapid heartbeat when taking levothyroxine.
• Sweating: Sweating and increased sensitivity to heat are common side effects of levothyroxine, especially if the dose is too high.
• Diarrhea: It can cause diarrhea in some people.
• Menstrual irregularities: In women, levothyroxine can affect menstrual periods, with some women experiencing heavier or more frequent periods.
• Muscle weakness: It can cause muscle weakness, especially in people with underlying muscle or nerve problems.

It is important to note that not everyone who takes levothyroxine will experience these side effects, and some people may experience other side effects not listed here. If you experience any new or worsening symptoms while taking levothyroxine, it is important to talk to a doctor.

What are the warnings associated with the Levothyroxine tablet?

Here are some precautions to consider when taking this medicine:

• Before starting Levothyroxine, tell your healthcare provider if you have any medical conditions, including heart disease, high blood pressure, or diabetes.
• Inform your healthcare provider of any other medications or supplements you are taking, as Levothyroxine may interact with certain drugs, such as blood thinners or antidepressants.
• Regular monitoring of thyroid function is necessary while taking Levothyroxine, to ensure that the medication is working effectively and that the dosage is appropriate.
• This medicine should not be used to treat obesity or weight loss, as it can cause serious and potentially life-threatening side effects.
• In case of an overdose or allergic reaction to Levothyroxine, seek immediate medical attention.
• Do not stop taking Levothyroxine or adjust the dosage without consulting an endocrinologist.

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Does Levothyroxine tablet react with medicines?

Here are some drugs that may interact with Levothyroxine:

• Antacids containing aluminum or magnesium
• Calcium supplements
• Iron supplements
• Cholestyramine
• Colestipol
• Rifampin
• Phenytoin
• Carbamazepine
• Sertraline
• Warfarin

What are the alternatives to the Levothyroxine tablet?

There are several substitutes for Levothyroxine that are available in the market. Some of the commonly used substitutes include:

• Liothyronine (T3)
• Desiccated thyroid extract
• Thyroid hormone analogs

Again, it is important to consult with the best endocrinologists before making any changes to medication treatment.

What happens with a Levothyroxine tablet Overdose?

An overdose of Levothyroxine can cause symptoms such as chest pain, rapid or irregular heartbeat, tremors, sweating, fever, and confusion. In severe cases, it can lead to seizures, coma, or even death. If you suspect an overdose, seek emergency medical attention immediately.

What happens if you miss the Levothyroxine dose?

If you miss a dose of Levothyroxine, take it as soon as you remember, unless it is almost time for your next scheduled dose. If you miss a dose, do not double up on your next dose. Instead, resume your regular dosing schedule. However, if you miss several doses in a row, contact your healthcare provider, as a dosage adjustment may be needed to maintain proper thyroid hormone levels.

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How to store Levothyroxine tablets?

Here are the guidelines for storing Levothyroxine:

• Store Levothyroxine tablets at room temperature (between 68°F and 77°F) in a dry place, away from light and moisture.
• Keep the medication in its original container, with the lid tightly closed.
• Do not store this tablet in the bathroom or in other areas with high humidity or moisture.
• Do not refrigerate or freeze Levothyroxine tablets.
• Keep this tablet out of reach of children and pets.
• If you have any expired or unused Levothyroxine tablets, dispose of them properly, and do not keep them in your home.

It is always mandatory to consult an expert before using any kind of medication. Therefore consult the doctor about your symptoms. If you want to take this medicine then do talk to an endocrinologist.

FAQs

How long does it take for levothyroxine to lower TSH?

Although levothyroxine begins to act right away, it can take a few weeks before your symptoms start to get better.

Is levothyroxine a lifelong treatment?

Levothyroxine maintenance therapy should often only be recommended in cases with obvious hypothyroidism.

Can you live a normal long life with hypothyroidism?

With the right care, a person with hypothyroidism typically has little to no decline in quality of life and a normal life expectancy.